COPD lungs

COPD stands for Chronic Obstructive Pulmonary Disease. It is a chronic and progressive respiratory condition that affects the lungs. COPD primarily includes two main conditions: chronic bronchitis and emphysema.

Chronic bronchitis is characterized by inflammation and irritation of the bronchial tubes, which are the airways that carry air to and from the lungs. This inflammation leads to increased mucus production, causing coughing and difficulty in breathing.

Emphysema, on the other hand, is characterized by the damage and destruction of the air sacs (alveoli) in the lungs. These air sacs are responsible for exchanging oxygen and carbon dioxide during the breathing process. With emphysema, the air sacs lose their elasticity, which impairs the ability to exhale properly.

The main cause of COPD is long-term exposure to irritants, especially cigarette smoke. Other factors that can contribute to COPD include exposure to second-hand smoke, occupational dust and chemicals, air pollution, and genetic factors. The common symptoms of COPD include shortness of breath, chronic cough, wheezing, chest tightness, fatigue, and frequent respiratory infections.

Over time, COPD can significantly impact a person’s quality of life, making simple activities like walking or climbing stairs difficult. While there is no cure for COPD, treatments aim to manage symptoms, improve lung function, and slow down the progression of the disease.

These treatments may include lifestyle changes (such as quitting smoking), medications (bronchodilators, inhaled steroids), pulmonary rehabilitation programs, supplemental oxygen therapy, and in severe cases, surgery (lung volume reduction surgery or lung transplantation).


There are hundreds of ongoing and completed clinical trials focused on COPD. These trials aim to evaluate the effectiveness and safety of various interventions, medications, and approaches in managing and treating COPD. Here are a few examples of areas where clinical trials are conducted in COPD:

  1. Medications and Therapies: Clinical trials test new medications, inhalers, and therapies to manage COPD symptoms, reduce exacerbations, and slow down disease progression. These trials may involve investigating the efficacy of bronchodilators, inhaled corticosteroids, combination therapies, and novel drug candidates.

  2. Pulmonary Rehabilitation: Pulmonary rehabilitation programs are comprehensive interventions that combine exercise training education, and support to improve the physical and emotional well-being of COPD patients. Clinical trials may evaluate the impact of different rehabilitation strategies, exercise protocols, and technologies in enhancing outcomes for individuals with COPD.

  3. Non-Pharmacological Interventions: Some clinical trials focus on non-pharmacological interventions such as respiratory devices, supplemental oxygen therapy, and surgical procedures. These trials aim to assess the effectiveness, safety, and potential benefits of these interventions in managing COPD symptoms and improving lung function.

  4. Disease Management and Education: Clinical trials may also examine the impact of disease management strategies, self-management programs, and educational interventions on COPD patients. These trials aim to enhance patient knowledge, self-care practices, and adherence to treatment plans.

  5. Biomarker Research: Biomarkers are measurable indicators that provide information about the presence, severity, or progression of a disease. Clinical trials may investigate various biomarkers, including blood markers, genetic markers, and imaging techniques, to better understand COPD, identify subtypes, predict disease progression, and personalize treatment approaches.


Clinical trials often test new medications or drug combinations to improve COPD management. These may include bronchodilators, anti-inflammatory drugs, mucolytics, or other targeted therapies. Some trials focus on developing more effective and targeted medications to reduce symptoms, prevent exacerbations, and slow down disease progression.

  • Biologic Therapies: Biologic therapies target specific pathways or molecules involved in COPD. These treatments aim to modify the immune response and reduce inflammation in the airways. Biologics can be administered via injections or infusions and may help improve lung function, reduce exacerbations, and enhance quality of life.
  • Gene Therapies: Gene therapies involve modifying or replacing genes associated with COPD to correct genetic defects or regulate specific biological processes. While still in early stages of development, gene therapies hold potential for addressing specific genetic mutations that contribute to COPD development and progression.
  • Stem Cell Therapies: Stem cell therapies are being investigated as potential treatments for COPD. These therapies aim to repair damaged lung tissue and promote lung regeneration. Different types of stem cells, such as mesenchymal stem cells, are being explored for their potential to reduce inflammation, improve lung function, and enhance tissue repair.
  • Targeted Therapies: Targeted therapies focus on specific molecular targets or pathways implicated in COPD. By identifying and targeting these specific factors, researchers aim to develop more personalized and effective treatments. These may include drugs that inhibit certain enzymes or molecules involved in inflammation, tissue damage, or airway constriction.

Our clinical research site and dedicated clinical investigators in pulmonology can contribute to the advancement of your study. Please contact us at and we would be excited to provide additional information on how we can support your clinical trial in COPD patients.

Investigational pulmonology team

Phase I clinical research center

DCC Convex